2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108251S
    Methotrexate metabolite-d3
    Methotrexate metabolite-d3 is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
    Methotrexate metabolite-d<sub>3</sub>
  • HY-132286S
    2-PADQZ-d8
    2-PADQZ-d8 is the deuterium labeled 2-PADQZ-d8.
    2-PADQZ-d<sub>8</sub>
  • HY-100662S
    Didesethyl chloroquine-d4
    Didesethyl chloroquine-d4 is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant.
    Didesethyl chloroquine-d<sub>4</sub>
  • HY-12772S2
    (2R,4S)-Hydroxy Itraconazole-d5
    		99.40%
    (2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole.
    (2R,4S)-Hydroxy Itraconazole-d<sub>5</sub>
  • HY-135111S
    4-Desmethoxy Omeprazole-d3
    4-Desmethoxy Omeprazole-d3 is the deuterium labeled 4-Desmethoxy Omeprazole. 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Kiof 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
    4-Desmethoxy Omeprazole-d<sub>3</sub>
  • HY-132770S
    Propafenone Dimer Impurity-d10
    Propafenone Dimer Impurity-d10 is the deuterium labeled Propafenone Dimer Impurity.
    Propafenone Dimer Impurity-d<sub>10</sub>
  • HY-178269
    SCH-720881
    SCH-720881 is the active metabolite of Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.
    SCH-720881
  • HY-124104
    Aldicarb sulfoxide
    		98.41%
    Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC50 of 10 μM for both in zebrafish.
    Aldicarb sulfoxide
  • HY-153408
    4-Hydroxylidocaine
    4-Hydroxylidocaine is a Lidocaine (HY-B0185) metabolite.
    4-Hydroxylidocaine
  • HY-131266R
    Febuxostat n-butyl isomer (Standard)
    Menadione bisulfite (sodium) (Standard) is the analytical standard of Menadione bisulfite (sodium). This product is intended for research and analytical applications. Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.
    Febuxostat n-butyl isomer (Standard)
  • HY-135586
    Raloxifene N-Oxide
    Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
    Raloxifene N-Oxide
  • HY-132569S
    8-Hydroxy warfarin-d5
    8-Hydroxy warfarin-d5 can be used as an internal standard for the quantification of Warfarin and its known metabolites.
    8-Hydroxy warfarin-d5
  • HY-119532R
    Nordeprenyl (Standard)
    Chromium picolinate (Standard) is the analytical standard of Chromium picolinate. This product is intended for research and analytical applications. Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.
    Nordeprenyl (Standard)
  • HY-131729
    16-Phenoxy tetranor Prostaglandin A2
    16-Phenoxy tetranor Prostaglandin A2 is a metabolite of uprostone and an analog of the antifertility hormone PGF2α.
    16-Phenoxy tetranor Prostaglandin A2
  • HY-20390S
    Lapatinib impurity 18-d4
    Lapatinib impurity 18-d4 is deuterium labeled 3-Chloro-4-((3-fluorobenzyl)oxy)aniline.
    Lapatinib impurity 18-d<sub>4</sub>
  • HY-148682R
    18β-Glycyrrhetyl-3-O-sulfate (Standard)
    (Z)-Methyl icos-11-enoate (Standard) is the analytical standard of (Z)-Methyl icos-11-enoate. This product is intended for research and analytical applications. (Z)-Methyl icos-11-enoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    18β-Glycyrrhetyl-3-O-sulfate (Standard)
  • HY-133774
    Trityl olmesartan medoxomil impurity III
    Trityl olmesartan medoxomil impurity III is an impurity of Trityl olmesartan medoxomil. Trityl olmesartan medoxomil is an intermediate of Olmesartan medoxomil.
    Trityl olmesartan medoxomil impurity III
  • HY-148377S
    Abiraterone sulfate N-oxide-d4 TEA
    Abiraterone sulfate N-oxide-d4 TEA is the deuterium labeled Abiraterone sulfate N-oxide TEA (HY-148377). Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer.
    Abiraterone sulfate N-oxide-d<sub>4</sub> TEA
  • HY-135151
    Difluoro atorvastatin
    Difluoro atorvastatin (Fluoroatorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    Difluoro atorvastatin
  • HY-12769R
    Mebeverine acid (Standard)
    Mebeverine acid (Mebeverine metabolite Mebeverine acid) (Standard) is the analytical standard for Mebeverine acid (HY-12769). This product is used for research and analytical applications. Mebeverine acid is a secondary metabolite of the intestinal antispasmodic Mebeverine (HY-A0078). Mebeverine acid is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid is an important marker of oral Mebeverine.
    Mebeverine acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity